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December 8, 2025BloodOpen Access

Second primary malignancies in multiple myeloma: Incidence, survival and prognostic factors from a large single-center observational study

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Authors

ADAndriy DerkachHLHeather LandauRFRoss Firestone

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Overview

Observational study found a 10-year cumulative incidence of second primary malignancies at 20% in multiple myeloma patients, suggesting key risk factors.

Key Points

  • Patients with multiple myeloma had a 10-year cumulative incidence of second primary malignancies at 20%.
  • Survival analysis showed a median overall survival of 15.6 years, with significant predictors identified, including smoking history.
  • This retrospective cohort study included 1,476 patients with a median follow-up of 5.7 years, focusing on risk factors for second primary malignancies.
  • Notable risks for developing second primary malignancies included older age, Caucasian race, and smoking history, indicating important clinical implications.

Cite This Study

Derkach et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d7e8https://doi.org/10.1182/blood-2025-2213
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Second Primary Malignancy in Multiple Myeloma: a retrospective monocentric analysis of Department of Hematology of the Oncologic Hospital from Cagliari2025
  2. 2Comparative Analysis of Primary and Second Primary Multiple Myeloma: A Propensity Score-Matched Study.2025
  3. 3Therapy-related malignancies in myeloma: SEER comparison of IMiD vs anti-CD38 eras2025
  4. 4Secondary multiple myeloma and antecedent cancer lineage.2026
  5. 5Early intervention in smoldering multiple myeloma: A systematic review of comparative prospective trials2025