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October 1, 2025

Comparative Analysis of Primary and Second Primary Multiple Myeloma: A Propensity Score-Matched Study.

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Authors

YJYoon Jung JangJKJoonseog KongHKHeyjin Kim

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Overview

Retrospective analysis shows no difference in overall survival between second primary multiple myeloma and primary multiple myeloma patients, suggesting similar treatment efficacy.

Key Points

  • No significant difference in overall survival was found between primary multiple myeloma and second primary multiple myeloma, with median survival of 45.1 and 41.5 months, respectively.
  • In the analyzed group, 83.3% of patients with second primary multiple myeloma had achieved remission of their initial malignancy before being treated for multiple myeloma.
  • Patient outcomes after aggressive treatment were similar between the two conditions, indicating the potential for similar management strategies.
  • Further larger prospective studies are needed to determine optimal treatment approaches for second primary multiple myeloma.

Cite This Study

Jang et al. (2025) studied this question.

synapsesocial.com/papers/68dd89defe798ba2fc497eb9https://doi.org/10.1177/11795549251377882
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Second Primary Malignancy in Multiple Myeloma: a retrospective monocentric analysis of Department of Hematology of the Oncologic Hospital from Cagliari2025
  2. 2Second primary malignancies in multiple myeloma: Incidence, survival and prognostic factors from a large single-center observational study2025
  3. 3Secondary multiple myeloma and antecedent cancer lineage.2026
  4. 4Therapy-related malignancies in myeloma: SEER comparison of IMiD vs anti-CD38 eras2025
  5. 5Survival impact of second primary cutaneous and non‐cutaneous melanoma in melanoma survivors2025