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December 8, 2025BloodOpen Access

Expanding access in pediatrics: Outcomes of haploidentical transplantation with reduced intensity and peripheral blood stem cells

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Authors

JCJulia E. Colunga‐PedrazaLVLaura Villarreal‐MartínezDGDavid Gómez‐Almaguer

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Overview

Retrospective analysis shows 79% overall survival in pediatric patients receiving haploidentical HSCT with PTCy, highlighting graft-versus-host disease risks and conditioning methods.

Key Points

  • Overall survival was 79% at one year and 68% at two years for pediatric patients undergoing haploidentical hemopoietic stem cell transplantation.
  • Cumulative incidence of acute graft-versus-host disease grades II-IV at day 100 was 36%, indicating a notable risk of complications.
  • Patients included in the retrospective study had hematological malignancies and received reduced-intensity conditioning regimens.
  • The use of total body irradiation in conditioning was associated with a 14.8% non-relapse mortality at one year.

Cite This Study

Colunga‐Pedraza et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd01https://doi.org/10.1182/blood-2025-7714
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