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July 26, 2026Immunopharmacology and Immunotoxicology

Quinic acid attenuates cisplatin-induced AKI by restoring antioxidant capacity and reducing inflammation.

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Why the study?

Does quinic acid attenuate cisplatin-induced acute kidney injury in a rat model?

Population

40 male Wistar rats

Comparison

Quinic acid administered orally at doses of 25… vs Cisplatin alone and untreated control

Design

Preclinical, randomly divided, blinded scoring for renal histopathology

Follow-up

14 days

Key result

Quinic acid (particularly at 50 and 100 mg/kg) significantly attenuated cisplatin-induced acute kidney injury by improving renal markers, restoring antioxidant capacity, and reducing inflammation.

Authors

MGMehdi GoudarziZLZohreh LamoochiSSSusan Sabbagh

Discussion

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Overview

QA attenuates cisplatin AKI in rats; leaves open translation to human chemotherapy patients.

Key Points

  • This study aims to assess the protective effect of quinic acid against cisplatin-induced acute kidney injury in rats.
  • Forty male Wistar rats were randomly divided into five groups (n=8) including control and treatment groups.
  • Cisplatin was administered at 7.5 mg/kg, with quinic acid given at 25, 50, or 100 mg/kg orally for 14 days prior to cisplatin administration.
  • Biochemical markers, oxidative stress indices, inflammatory cytokines, and apoptotic gene expression were assessed.
  • Cisplatin caused severe renal dysfunction and increased oxidative stress, inflammation, and apoptosis.
  • Quinic acid significantly improved renal markers, reduced oxidative stress (MDA, NO), and downregulated inflammatory cytokines (TNF-α, IL-1β).
  • Higher doses of quinic acid enhanced Nrf2-pathway protein levels and reduced histological injury scores significantly.

Study Design

Type

RCT (n=40)

Blinding

Single-blind

Randomization

Randomly divided

Structured PICO

Does quinic acid attenuate cisplatin-induced acute kidney injury in a rat model?

P
Population
40 male Wistar rats subjected to cisplatin-induced acute kidney injury, treated with quinic acid for 14 days prior to cisplatin challenge.
I
Intervention
Quinic acid (QA) administered orally at doses of 25, 50, or 100 mg/kg once daily for 14 days before cisplatin challenge (7.5 mg/kg, i.p.)
C
Comparator
Cisplatin alone (7.5 mg/kg, i.p.) and untreated control
O
Outcome
Biochemical markers of renal injury (BUN, creatinine, KIM-1, NGAL), oxidative stress indices, inflammatory cytokines, apoptotic gene expression, Nrf2 pathway proteins, and renal histopathologysurrogate

Quinic acid demonstrates nephroprotective effects against cisplatin-induced acute kidney injury in rats through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms.

Cite This Study

Goudarzi et al. (2026) conducted an RCT in Cisplatin-induced acute kidney injury (n=40). Quinic acid vs. Cisplatin alone and healthy control was evaluated on Biochemical markers of renal dysfunction, oxidative stress indices, inflammatory cytokines, apoptotic gene expression, and Nrf2 pathway proteins. Quinic acid (particularly at 50 and 100 mg/kg) significantly attenuated cisplatin-induced acute kidney injury by improving renal markers, restoring antioxidant capacity, and reducing inflammation.

synapsesocial.com/papers/6a65a91fd3aea3239cd79281https://doi.org/10.1080/08923973.2026.2705914
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Functional, Structural and Genetic Modulation in Plasma and Renal Antioxidant Systems by Quercetin, Catechin and Genistein in Cisplatin‐Induced Acute Nephrotoxicity in Wistar Rats2025 · 3 citations
  2. 2Amelioration of cisplatin-induced ototoxicity by thymoquinone in male Wistar rats2024
  3. 3Quinolinic acid metabolism may mitigate AKI to CKD transition2025
  4. 4Protective Effects of Quercetin Against Vincristine-Induced Nephrotoxicity via Modulation of Oxidative Stress, Inflammation, and Apoptosis in Rats.2025 · 4 citations
  5. 5Riociguat Alleviates Cisplatin-Caused Kidney Injury by Suppressing Oxidative Stress and Inflammation2025