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July 30, 2025Journal of Clinical MedicineOpen Access

Impact of Perioperative Antibiotic Prophylaxis in Caesarean Section on the Maternal Gut Microbiome: A Systematic Review

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Authors

EFElisabeth FelesCNClaudio NeidhöferCWChristina Wessels

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Overview

Systematic review reveals antibiotic prophylaxis alters maternal gut microbiome, highlighting variability in outcomes and the need for further studies.

Key Points

  • Maternal gut microbiome may be disrupted by antibiotic prophylaxis in caesarean section, impacting recovery.
  • Review analyzed three studies involving 286 mothers, all showing inconsistent microbiome outcomes post-antibiotic exposure.
  • Current literature relies on diverse methodologies which limit comparability of microbiome metrics like alpha and beta diversity.
  • Understanding the maternal gut microbiome is crucial for neonatal health and warrants further focused research.

Cite This Study

Feles et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8ceea4https://doi.org/10.3390/jcm14145104
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association between Timing of Prophylactic Antibiotic in Cesarean Section and Risk of Postpartum and Neonatal Infections2025
  2. 2Improving immune‐related health outcomes post‐cesarean birth with a gut microbiome‐based program: A randomized controlled trial2025 · 4 citations
  3. 3Antibiotic prophylaxis for neonatal surgery: Evaluation of the implementation of a new protocol based on “less could be better”2025
  4. 4Perioperative antibiotic prophylaxis of infections in abdominal surgery: evidence–based medicine and current trends2025
  5. 5Impact of Prior Cesarean Section on Surgical Site Infections, Microbiological patterns, and Surgical Outcomes: A Prospective Multicenter Cohort Study in South Ethiopia2025