Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 10, 2025Molecular NeurodegenerationOpen Access

APOE genotype influences on the brain metabolome of aging mice – role for mitochondrial energetics in mechanisms of resilience in APOE2 genotype

View Full Paper
Ask AI
Bookmark
Share

Authors

KBKamil BorkowskiNLNuanyi LiangNZNa Zhao

Discussion

Loading...

Member takes

Overview

Investigating changes in the brain metabolome with aging in mice, highlighting APOE genotype influences on fatty acid metabolism.

Key Points

  • APOE2 genotype is associated with improved BCAA utilization in the TCA cycle, enhancing energy production during aging.
  • Increased C5 acylcarnitine levels and altered BCAA profiles were observed in aging APOE2 mice, indicating metabolic resilience.
  • Changes in metabolites like acylcarnitines and amino acids suggest declining fatty acid β-oxidation, potentially linked to mitochondrial dysfunction.
  • Findings reveal how APOE genotype impacts brain aging processes, providing insights into Alzheimer's disease risk.

Cite This Study

Borkowski et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d6478202chttps://doi.org/10.1186/s13024-025-00888-z
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1APOE genotype-dependent differences in human astrocytic energy metabolism2025 · 5 citations
  2. 2Fueling the brain - the role of apolipoprotein E in brain energy metabolism and its implications for Alzheimer’s disease2025 · 19 citations
  3. 3Long-term Dietary Fat Intervention Affects Retinal Health in APOE Mice2025
  4. 4Ketogenic Diet Modulates Gut Microbiota–Brain Metabolite Axis in a Sex‐ and Genotype‐Specific Manner in <scp>APOE4</scp> Mice2025
  5. 5Impact of APOE on cerebrovascular lipid profile in Alzheimer’s disease2025 · 7 citations