Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 25, 2025Translational PsychiatryOpen Access

Fueling the brain - the role of apolipoprotein E in brain energy metabolism and its implications for Alzheimer’s disease

View Full Paper
Ask AI
Bookmark
Share

Authors

VBVanessa BudnyIRIván RuminotMWMaha Wybitul

Discussion

Loading...

Member takes

Overview

This review reveals how apolipoprotein E isoforms affect energy metabolism in the brain, indicating implications for Alzheimer's disease.

Key Points

  • APOE4 is the strongest genetic risk factor for Alzheimer's disease, impacting brain energy metabolism.
  • The review highlights evidence showing that different APOE isoforms distinctly influence bioenergetic homeostasis in the brain.
  • Current understanding of APOE's role in energy metabolism remains unclear, suggesting a need for further research.
  • Investigating the interplay between APOE and energy metabolism may unveil new pathways in Alzheimer's disease pathology.

Cite This Study

Budny et al. (2025) studied this question.

synapsesocial.com/papers/68af7b247567bf4f94ff2eb9https://doi.org/10.1038/s41398-025-03550-w
View Full Paper
Ask AI
Bookmark
Share