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September 5, 2025Journal of Neurochemistry

Ketogenic Diet Modulates Gut Microbiota–Brain Metabolite Axis in a Sex‐ and Genotype‐Specific Manner in APOE4 Mice

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Authors

KIKira L. IvanichAYAndrew YackzanAFAbeoseh Flemister

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Overview

Dietary interventions improved neuroprotection and microbiome diversity in APOE4 carriers, suggesting benefits for Alzheimer's prevention.

Key Points

  • The ketogenic diet significantly improved brain metabolite levels, showing positive effects in APOE4 female mice.
  • Increased beneficial microbes like Lactobacillus correlated with enhanced brain health markers, while harmful species decreased.
  • Shotgun metagenomics and brain metabolomics were utilized to analyze changes in gut bacteria and metabolites linked to neuroprotection.
  • These findings support using a ketogenic diet as a targeted nutritional strategy to reduce the risk of Alzheimer's, especially for APOE4 carriers.

Cite This Study

Ivanich et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477f0bbhttps://doi.org/10.1111/jnc.70216
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