August 2, 2025Open Access

Long-term Dietary Fat Intervention Affects Retinal Health in APOE Mice

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Long-term dietary intervention reveals retinal dysfunction in APOE4 mice, indicating the role of dietary fat in metabolic health.

APOE4 mice are more vulnerable to dietary fat, showing early glucose intolerance after 2 months on a Western diet.
Retinal health deteriorates in APOE4 mice due to Western diet, indicated by swelling and degeneration at 12 months.
APOE3 mice only show retinal impairment after prolonged exposure, highlighting differences in dietary fat tolerance.
Control diet improves glucose metabolism but fails to prevent retinal dysfunction in APOE4 mice, indicating the need for tailored dietary strategies.

Abhyankar et al. (2025) studied this question.

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