Role of cellular senescence in hepatic diseases (Review)

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Review reveals strong connection between cellular senescence and clinical outcomes in hepatic disorders, suggesting new therapeutic targets.

Increased cellular senescence worsens clinical outcomes in various hepatic disorders, contributing to age-related pathologies.
Several pharmacological strategies aim to target senescence markers and inhibit the senescence-associated secretory phenotype.
This review highlights key molecular pathways and biomarkers linked to hepatic senescence and their potential therapeutic roles.
Addressing cellular senescence in liver diseases may help alleviate inflammation and improve patient health outcomes.

Xing et al. (2025) studied this question.

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Review reveals strong connection between cellular senescence and clinical outcomes in hepatic disorders, suggesting new therapeutic targets.