August 4, 2025Cell Death DiscoveryOpen Access

Hallmarks and mechanisms of cellular senescence in aging and disease

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Perspective discusses how cellular senescence impacts aging and chronic diseases, highlighting regulatory pathways and potential therapies.

Cellular senescence is critical for development and acts as a barrier against tumorigenesis.
Persistent activation of senescence contributes to chronic diseases like cancer and pulmonary disorders.
The accumulation of senescent cells is linked to the aging process and various health issues.
Understanding senescence could lead to new therapeutic opportunities for managing aging-related diseases.

Ajoolabady et al. (2025) studied this question.

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Perspective discusses how cellular senescence impacts aging and chronic diseases, highlighting regulatory pathways and potential therapies.