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September 10, 2025Open Access

Disruption of nucleolar integrity triggers cellular quiescence through organelle rewiring and secretion

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Authors

PRPrashant RawatTQTabea QuadererIKIno D. Karemaker

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Overview

Multi-omics analysis reveals how nucleolar dysfunction affects cellular quiescence through TP53 and secretory pathways.

Key Points

  • Nucleolar disruption activates a TP53-dependent program, leading to prolonged cellular quiescence, enhancing survival.
  • The study uncovers 400 regulators involved in secretory and quiescent states linked to nucleolar stress.
  • Functional genomics and multi-omics profiling were used to define the cellular consequences of nucleolar disruption.
  • Findings suggest nucleolar stress responses are integral to cancer progression associated with ribosomopathies.

Cite This Study

Rawat et al. (2025) studied this question.

synapsesocial.com/papers/68c23abeb210217d64781651https://doi.org/10.1101/2025.08.28.672879
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CHIP, VCP, and Nucleolar Gatekeepers Remodel the Nucleolus into a Stress-Responsive Proteostasis Hub2025
  2. 2Nucleolar Organization in Response to Transcriptional Stress2025
  3. 3The Nucleolus and Its Associated Pathologies2025
  4. 4"Genome Stability under Silence: DNA Repair Networks in Quiescent Fission Yeast"2025 · 1 citations
  5. 5Intergenic accumulation of RNAPII maintains the potential for swift transcriptional restart upon release from quiescence.2025