August 25, 2025Open Access

"Genome Stability under Silence: DNA Repair Networks in Quiescent Fission Yeast"

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Research uncovers mechanisms of DNA repair in quiescent cells, indicating their role in genome stability.

Quiescent cells maintain genome stability by counteracting DNA lesions, especially uracil residues, through DNA repair networks.
Analysis revealed that distinct lesion types accumulate in quiescent cells, impacting genome integrity and recovery post-quiescence.
Using Schizosaccharomyces pombe, several DNA repair mechanisms, such as base excision repair, were identified as crucial for genome surveillance.
These findings suggest that understanding DNA repair in non-dividing cells may have implications for aging and cancer dormancy.

Samia Miled (2025) studied this question.

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August 25, 2025Open Access

View Full Paper

Ask AI

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Authors

Research uncovers mechanisms of DNA repair in quiescent cells, indicating their role in genome stability.

Quiescent cells maintain genome stability by counteracting DNA lesions, especially uracil residues, through DNA repair networks.
Analysis revealed that distinct lesion types accumulate in quiescent cells, impacting genome integrity and recovery post-quiescence.
Using Schizosaccharomyces pombe, several DNA repair mechanisms, such as base excision repair, were identified as crucial for genome surveillance.
These findings suggest that understanding DNA repair in non-dividing cells may have implications for aging and cancer dormancy.

Samia Miled (2025) studied this question.

View Full Paper

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