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July 30, 2025Cancer ScienceOpen Access

Nucleolar Organization in Response to Transcriptional Stress

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Authors

RIRikiya ImamuraTYTakaaki Yasuhara

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Overview

Review summarizes nucleolar changes due to transcriptional stress, highlighting implications for rDNA instability in cancer.

Key Points

  • MAIN FINDING: Nucleolar organization changes significantly in response to transcriptional stress, affecting cellular functions.
  • KEY EVIDENCE: Recent findings show diverse nucleolar proteins, with only 30% involved in ribosome production, indicating multifunctionality.
  • APPROACH: The review focuses on the molecular mechanisms of nucleolar changes observed under stressors like nutrient starvation and DNA damage.
  • SIGNIFICANCE: Understanding nucleolar stress and rDNA instability could provide insights into cancer development and therapeutic interventions.

Cite This Study

Imamura et al. (2025) studied this question.

synapsesocial.com/papers/689a0945e6551bb0af8cedd0https://doi.org/10.1111/cas.70164
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Anticancer drug development against ribosome synthesis and the nucleolus2025
  2. 2Disruption of nucleolar integrity triggers cellular quiescence through organelle rewiring and secretion2025
  3. 3The Nucleolus and Its Associated Pathologies2025
  4. 4RNA Polymerase II-mediated transcription is required for repair of ribosomal DNA breaks in nucleolar caps, guarding against genomic instability2025
  5. 5CHIP, VCP, and Nucleolar Gatekeepers Remodel the Nucleolus into a Stress-Responsive Proteostasis Hub2025