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September 5, 2025Open Access

Figure S3 from NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1-Mutant Melanoma

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Authors

MIMilad IbrahimIIIrineu Illa-BochacaGJGeorge Jour

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Overview

Loss of NF1 promotes EGFR and downstream signaling in melanoma cells, indicating therapeutic targets.

Key Points

  • NF1-loss leads to increased EGFR activity and dysregulation of key signaling pathways, enhancing treatment sensitivity.
  • Key findings include the activation of AKT and ERK signaling pathways in NF1-deficient melanoma cells.
  • Observational analysis reveals complex interactions between NF1 status and EGFR signaling in melanoma.
  • These findings highlight potential targets for improving therapeutic strategies in melanoma with NF1 mutations.

Cite This Study

Ibrahim et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477fbcdhttps://doi.org/10.1158/0008-5472.30029885
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Figure S5 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  2. 2Figure S2 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  3. 3Figure S4 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  4. 4Table S2 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025
  5. 5Table S7 from <i>NF1</i> Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in <i>NF1</i>-Mutant Melanoma2025