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September 5, 2025Molecular Nutrition & Food ResearchOpen Access

Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index

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Authors

TSTatjana SeitzJVJenni ViitaharjuCBChouaib Benchraka

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Overview

This research reveals how gestational diabetes mellitus and body mass index affect breast milk proteins across lactation stages.

Key Points

  • The study identifies 3496 proteins in breast milk, with 1055 being differentially abundant between colostrum and mature milk.
  • Alterations in breast milk proteome due to BMI and gestational diabetes mellitus were observed, indicating potential impacts on infant health.
  • Colostrum showed higher levels of proteins related to the immune system, while mature milk had proteins linked to lipid biosynthesis.
  • Further understanding is needed of how these proteomic changes influence a child's health in the long term.

Cite This Study

Seitz et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477f7b2https://doi.org/10.1002/mnfr.70225
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolomic Signatures of Transitional Breast Milk in Gestational Diabetes Mellitus: A Case–Control Study Assessing the Impact of Insulin Therapy2025
  2. 2A Microbiota Profiling of Breast Milk in Relation to Gestational Diabetes Mellitus Status - A Greek pilot study2025
  3. 3Unraveling Stage-Specific Metabolites in Human Milk and Their Links to Maternal Physiology: Insights from a Mexican Population2025
  4. 4Influence of Gestational Age on the Level of Functional Peptides (Peptidome) in Breast Milk2025
  5. 5Amino Acid Profile Alterations in the Mother–Fetus System in Gestational Diabetes Mellitus and Macrosomia2025