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August 22, 2025NutrientsOpen Access

Influence of Gestational Age on the Level of Functional Peptides (Peptidome) in Breast Milk

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Authors

AAAnna-Lena AbelsJRJohanna RuhnauTITill Ittermann

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Overview

Observational study identifies differences in peptidome of breast milk from preterm and term infants, suggesting unique nutritional needs.

Key Points

  • A total of 130 peptides derived from 19 proteins showed significant differences between preterm and term milk, impacting infant development.
  • Observational analysis of breast milk from 10 preterm and 13 term infants revealed a diverse peptidome composition across gestational ages.
  • Non-targeted tandem mass spectrometry analysis demonstrated a total of 4570 quantified peptides, highlighting the complexity of the milk peptidome.
  • The findings underscore the need to address special nutritional needs in preterm infants, emphasizing the role of specific peptides in their development.

Cite This Study

Abels et al. (2025) studied this question.

synapsesocial.com/papers/68af735d7567bf4f94fecf60https://doi.org/10.3390/nu17172724
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dynamic Variations in Endogenous Peptides in Chinese Human Milk Across Lactation and Geographical Regions2025
  2. 2Breast Milk Proteome: Changes in the Different Stages of Lactation and Impacts of Gestational Diabetes Mellitus and Body Mass Index2025
  3. 3Differential Expressions of Immunoregulatory microRNAs in Breast Milk of Mothers of Preterm Versus Term Infants: A Preliminary Study2025
  4. 4Unraveling Stage-Specific Metabolites in Human Milk and Their Links to Maternal Physiology: Insights from a Mexican Population2025
  5. 5Fatty Acid Profiling of Breast Milk at Different Gestational Ages2025