Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
September 5, 2025Frontiers in ImmunologyOpen Access

TRP-related gene signatures predict survival and the immune microenvironment in rectal cancer: a comprehensive bioinformatics study

View Full Paper
Ask AI
Bookmark
Share

Authors

XWXiaojun WangJPJieqiong PengSDSong Dong

Discussion

Loading...

Member takes

Overview

Bioinformatics analysis reveals five biomarkers impacting rectal cancer prognosis and immune response.

Key Points

  • Five TRP-related biomarkers correlated with rectal cancer prognosis were identified, enhancing understanding of disease mechanisms.
  • Analysis of 1,989 differentially expressed genes revealed 246 TRP-related genes, indicating their significance in metabolic pathways.
  • Immune cell infiltration analysis showed distinct ratios between high- and low-risk patients, highlighting TRP gene influence.
  • Targeted drugs related to identified biomarkers may offer therapeutic options, emphasizing the need for personalized cancer treatment.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/68c23a2cb210217d6477f49bhttps://doi.org/10.3389/fimmu.2025.1605124
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of RNA binding protein genes associated with colorectal cancer by bioinformatics analysis2025 · 1 citations
  2. 2Molecular clustering and prognostic features based on integrated databases predict survival and immune status in patients with gastric cancer2025 · 1 citations
  3. 3Role of necroptosis-related genes in immune activity and prognosis of colorectal cancer2025 · 3 citations
  4. 4Identification of hub genes predicting sensitivity to neoadjuvant chemoradiation in locally advanced rectal cancer2025
  5. 5TRP channels in hepatocellular carcinoma: integrative Mendelian randomization and multi-omics analyses highlight MCOLN3/TRPV4 as candidate dual-effect biomarkers2025