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September 10, 2025Frontiers in OncologyOpen Access

Molecular clustering and prognostic features based on integrated databases predict survival and immune status in patients with gastric cancer

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Authors

YSYin ShiJZJiaying ZhouKJKatrina Jia

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Overview

Comprehensive bioinformatics analysis predicts survival outcomes in gastric cancer patients, highlighting prognostic biomarkers and immune status.

Key Points

  • Elevated prognostic features indicate worse survival outcomes in high-risk gastric cancer patients, emphasizing tailored treatment strategies.
  • Key genes such as CTHRC1, CST6, and AKR1B1 serve as significant independent prognostic factors, correlating with immune cell functions.
  • Bioinformatics approach integrating TCGA and GEO data established robust survival prediction models, enabling stratification of patients.
  • Significant differences in gene expression profiles between normal and cancer tissues suggest potential therapeutic targets and biomarker candidates.

Cite This Study

Shi et al. (2025) studied this question.

synapsesocial.com/papers/68c23bd7b210217d64786503https://doi.org/10.3389/fonc.2025.1642911
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