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September 10, 2025Radiology and OncologyOpen Access

Identification of hub genes predicting sensitivity to neoadjuvant chemoradiation in locally advanced rectal cancer

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Authors

QZQunye ZhaoCZChuang ZhangXZX. Zhang

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Overview

This analysis identifies hub genes predicting neoadjuvant chemoradiation response in locally advanced rectal cancer, suggesting potential biomarkers for personalized therapy.

Key Points

  • The study identifies six hub genes related to neoadjuvant chemoradiation sensitivity in locally advanced rectal cancer.
  • Differential expression analysis revealed 2619 up-regulated and 2466 down-regulated genes between sensitive and resistant patients.
  • Using PPI networks, six key hub genes were identified, with analysis showing their potential as predictive biomarkers for therapy response.
  • Results indicated no significant association between the identified hub genes and immune cell infiltration in this cancer subtype.

Cite This Study

Zhao et al. (2025) studied this question.

synapsesocial.com/papers/68c241efb210217d647a1afahttps://doi.org/10.2478/raon-2025-0005
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