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September 5, 2025Pharmacy EducationOpen Access

Virtual screening of metabolites from mulberry (Morus alba L.) leaves as anti-hyperglycemic agents through molecular docking against multiple targets

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Authors

WPWimzy Rizqy PrabhataGPGinanjar PratamaSKShilvia Anggun Tiara Kaldella

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Overview

Molecular docking identifies metabolites from mulberry leaves as promising anti-hyperglycemic agents, implying the need for further bioavailability studies.

Key Points

  • Sixteen compounds showed top docking scores against 12 targets related to hyperglycemia, indicating potential efficacy.
  • Sanggenol M ranked high against 7 targets including alpha-glucosidase and glucagon receptor, highlighting its multi-target potential.
  • Analysis based on Lipinski’s rule and BOILED-Egg diagram suggested Sanggenol M has poor oral bioavailability, demanding further development.
  • The study utilized molecular docking to screen 157 metabolites, emphasizing in silico approaches for drug discovery.

Cite This Study

Prabhata et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477e402https://doi.org/10.46542/pe.2025.252.814
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Elucidating Key Components and Mechanisms Underlying the Synergistic Anti-Type 2 Diabetes Effect of Morus alba L. and Siraitia grosvenorii Combination: An Integrated In Vitro Enzymology, Untargeted Metabolomics, and Network Pharmacology Approach2025
  2. 2Molecular Mechanism of Mulberrin Regulating Lipid Metabolism Homeostasis Based on the Gut–Liver Axis Fiaf/AMPK Signaling Pathway2025
  3. 3Quantification of 1-deoxynojirimycin content, ?-amylase inhibition activity, and secondary metabolites in four different mulberry accession leaves from Indonesia2025
  4. 4Mulberry (Morus spp.): A Comprehensive Review of Its Medicinal and Functional Properties2025
  5. 5Enhancement of α-Glucosidase Inhibitory Activity, Antioxidant Activity, and Antioxidant Compounds in Mulberry Leaves Under Salinity Stress2025