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December 8, 2025BloodOpen Access

Targeting METTL3 disrupts oncogenic transcriptional programs and activates immune and apoptotic pathways in Acute Myeloid Leukemia

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QWQian Wang

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Overview

Observational analysis reveals METTL3 impacts apoptosis and immune activation in Acute Myeloid Leukemia, indicating it could be a novel treatment target.

Key Points

  • Treatment with ZW27941 upregulated immune activation markers like IL-2 and IL-6 in Acute Myeloid Leukemia cells, reducing tumor survival.
  • RNA-seq analysis showed 534 genes were upregulated while 641 were downregulated, affecting lipid metabolism and drug resistance.
  • The approach included gene ontology analysis of differentially expressed genes after METTL3 degradation using ZW27941 in AML cells.
  • Findings highlight METTL3's potential as a therapeutic target in AML, as it influences key pathways for immune and apoptotic response.

Cite This Study

Qian Wang (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e4f4https://doi.org/10.1182/blood-2025-6764
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Also Consider

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  1. 1Targeting O-GlcNAcylated METTL3 impedes MDS/AML progression via diminishing SRSF1 m6A modification2025 · 1 citations
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  3. 3METTL13 Promotes Pre-Leukemic Transformation and the Development of Pediatric Leukemia2025
  4. 4HOXA9/METTL3/BMI1 axis is required for promoting anthracycline resistance in acute myeloid leukemia cells by modulating BMI1 expression through mRNA m6A modification2025
  5. 5METTL3: A dual regulator of oral tissue regeneration and malignancy with therapeutic implications for stem cell therapy and chemoresistance2025 · 1 citations