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September 5, 2025Open Access

Asymmetric induction of IL-23R by CpG and IL-15 in proliferative CLL fractions highlights intraclonal heterogeneity in chronic lymphocytic leukemia

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Authors

MCMartina CardilloNBNadia BertolaFFFabiana Ferrero

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Overview

Investigation shows CpG and IL-15 boost IL-23R expression in proliferative CLL, implying significant intraclonal heterogeneity.

Key Points

  • CpG and IL-15 stimulation increases IL-23R levels in proliferative CLL fractions, impacting immune response.
  • Higher IL-23R expression in proliferative CLL cells compared to resting fractions indicates asymmetrical receptor distribution.
  • Findings suggest that IL-23 signaling dominates over IL-12, potentially facilitating leukemic cell survival.
  • This imbalance between IL-23 and IL-12Rbeta2 induction points to a vital pathogenic mechanism that could be targeted therapeutically.

Cite This Study

Cardillo et al. (2025) studied this question.

synapsesocial.com/papers/68c239e5b210217d6477df42https://doi.org/10.1101/2025.08.27.672649
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IL‑10 limits CLL progression by reprogramming T cell exhaustion and myeloid suppression2025
  2. 2Dynamic crosstalk between CLL cells and lymph node fibroblasts promotes a pro-tumor microenvironment2025
  3. 3Clinical and biological impact of plasma cytokine levels in newly diagnosed chronic lymphocytic leukemia2025
  4. 4Role of the immune microenvironment in the clonal evolution of chronic lymphocytic leukemia2025
  5. 5Spatial transcriptomic analysis of chronic lymphocytic leukemia lymph nodes reveals tumor microenvironment evolution during disease progression2025