Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

IL‑10 limits CLL progression by reprogramming T cell exhaustion and myeloid suppression

View Full Paper
Ask AI
Bookmark
Share

Authors

AFAlessia FloerchingerHBHannah Briesch

Discussion

Loading...

Member takes

Overview

Analysis of IL-10 effects revealed increased cytokine production and reduced T cell exhaustion in CLL, suggesting potential therapeutic strategies with ibrutinib.

Key Points

  • IL-10 reprograms T cell exhaustion and enhances cytokine production in the tumor microenvironment.
  • Treatment with IL-10 substantially reduced exhausted T cells and targeted monocyte populations.
  • Investigative techniques included single-cell RNA-sequencing to evaluate immune responses in CLL.
  • Combination with ibrutinib suggests enhanced disease control, indicating new immunotherapeutic pathways.

Cite This Study

Floerchinger et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc65https://doi.org/10.1182/blood-2025-242
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1IL-17–Induced CD70 expression promotes T-cell suppression in DLBCL: Implications for immune escape and T-cell exhaustion2025
  2. 2Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target2025
  3. 3Asymmetric induction of IL-23R by CpG and IL-15 in proliferative CLL fractions highlights intraclonal heterogeneity in chronic lymphocytic leukemia2025
  4. 4Timed PD-1 blockade synergizes with IL-7/CCL19 armoring to reverse CAR-T exhaustion in PD-L1-high large B-cell lymphoma2025
  5. 5Peripheral immune checkpoints predict prognosis and reveal PD-1/treg/IL-10 crosstalk in B cell lymphoma2025