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December 8, 2025BloodOpen Access

Dynamic crosstalk between CLL cells and lymph node fibroblasts promotes a pro-tumor microenvironment

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Authors

AFAntonio FerreiraMCMartina CardilloNCNicholas Chiorazzi

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Overview

Analysis reveals lymphotoxin and chemokines drive fibroblast changes in chronic lymphocytic leukemia, suggesting potential therapeutic targets.

Key Points

  • Chronic lymphocytic leukemia cells promote changes in lymph node fibroblasts, enhancing tumor progression.
  • Lymphotoxin secretion from CLL cells correlated with increased chemokine production and fibroblast activation.
  • Observational analysis of chronic lymphocytic leukemia patient samples reveals fibroblasts as active participants.
  • Therapeutic targeting of lymphotoxin signaling may disrupt supports in the chronic lymphocytic leukemia microenvironment.

Cite This Study

Ferreira et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc6fhttps://doi.org/10.1182/blood-2025-241
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