September 5, 2025GeroScienceOpen Access

Failure of efficient cardiac proteostatic adaptations to chronic cAMP-stress is associated with accelerated heart aging

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Observational analysis shows impaired proteostasis in aged mice with chronic cAMP stress, suggesting accelerated cardiomyopathy.

Impaired proteostasis leads to increased cardiomyopathy in aged mice under chronic cAMP stress.
Markers of protein quality control mechanisms decline significantly from young to aged TG AC8 mice.
This study used cardiac-specific over-expression models to assess proteostasis across aging.
Findings highlight the need for better understanding of proteostasis mechanisms in promoting heart health.

Perino et al. (2025) studied this question.

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