Abstract Wed076: Chronic reductive stress and proteotoxicity induce left ventricular dyssynchrony with increased Tei index

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Severe segmental dyssynchrony emerged at 6 months in both CaNrf2-TGL and CaNrf2-TGH mice, indicating significant cardiac dysfunction.
Elevated TEI index of 2 to 4-fold in CaNrf2-TGL and CaNrf2-TGH mice suggests compromised systolic and diastolic cardiac functions.
ER stress linked to chronic reductive stress contributed to protein misfolding and structural disorganization within myocardium.
Longitudinal strain analysis highlighted moderate to severe endocardial deformation in TGH hearts at just 3 months.

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This analysis reveals that chronic reductive stress impairs cardiac function in mice, suggesting implications for treatment strategies.

Sunny et al. (2025) studied this question.

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