Abstract Wed018: Modulating mitochondrial protein quality control in age-induced cardiac dysfunction

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This research shows CLPB's role in mitigating cardiac dysfunction in aging mice, suggesting benefits in aged populations.

CLPB loss improved mitochondrial function and cardiac performance in aging SAMP8 mice and doxorubicin-treated HL-1 cells.
Echocardiographic assessments indicated enhanced ejection fraction in CLPB knockout mice compared to controls.
Mitochondrial chaperonin CLPB shows age-dependent expression reduction in SAMP8 mice, linking it to heart disease.
Doxorubicin treatment in HL-1 cells confirmed CLPB's role in moderating ROS levels and maintaining mitochondrial integrity.

Kashyap et al. (2025) studied this question.

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