This review highlights how aging impacts endothelial cells and gut microbiota, suggesting a link to atherosclerosis progression.
Key Points
Aging gut microbiota influences immune response, contributing to atherosclerosis progression and complexity.
Significant changes in the endothelial cells were noted with aging, correlating with high levels of oxidative stress and low butyrate production.
The review synthesizes current knowledge on gut microbiota's role in atherosclerosis, focusing on butyrate's protective effects in elderly individuals.
In-depth analysis shows that oxidative low-density lipoprotein uptake by foam cells leads to artery dysfunction, worsening atherosclerosis.