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September 10, 2025Molecular MetabolismOpen Access

Genetic and sex-specific regulation of mitochondrial function in gonadal and inguinal adipose tissue

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Authors

DKDorota KamińskaCPCalvin Q. PanLVLaurent Vergnes

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Overview

Analysis reveals mitochondrial gene expression impacts metabolic health in gonadal and inguinal adipose tissue, suggesting sex-specific regulation.

Key Points

  • Higher mitochondrial function in female gonadal adipose tissue correlates with metabolic traits, indicating sex-linked differences.
  • In contrast, male inguinal adipose tissue exhibits elevated mitochondrial content and oxidative phosphorylation expression.
  • Distinct genetic markers and regulators show varying expression patterns in adipose tissues of both sexes, influencing metabolic strategies.
  • The analysis underlines the importance of considering both sex and adipose depot in studies of metabolic health.

Cite This Study

Kamińska et al. (2025) studied this question.

synapsesocial.com/papers/68c24126b210217d6479e413https://doi.org/10.1016/j.molmet.2025.102227
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