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August 25, 2025Lipids in Health and DiseaseOpen Access

Adipose-specific HuR deletion protects against high-fat diet-induced obesity in mice through upregulating Ucp1 expression

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Authors

XFXiuqin FanYWYuanyuan WangPLPing Li

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Overview

Adipose-specific HuR deletion reduces obesity from a high-fat diet, suggesting a role in thermogenic regulation.

Key Points

  • Adipose-specific HuR deletion reduces body weight gain in mice on a high-fat diet, promoting fat browning.
  • Mice with HuR knockout showed increased Ucp1 levels, a gene essential for thermogenesis, enhancing energy expenditure.
  • Study employed RNA sequencing and assays to analyze HuR's role in regulating fat-related genes, focusing on Ucp1 expression.
  • Results highlight a protective mechanism against obesity through enhanced adipose thermogenesis, warranting further exploration.

Cite This Study

Fan et al. (2025) studied this question.

synapsesocial.com/papers/68af7b1f7567bf4f94ff2c75https://doi.org/10.1186/s12944-025-02680-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Human-Specific Suppression of Hepatic Fatty Acid Catabolism by RNA-Binding Protein HuR2025
  2. 2RNA binding protein HuD regulates fatty acid oxidation in pancreatic β-cells by modulating long-chain acyl-CoA dehydrogenase expression2025
  3. 3HuR enhances the stability of FGF19 mRNA to suppress Kupffer cell activation and mitigate inflammation and fibrosis in non-alcoholic fatty liver disease2025
  4. 4The RNA-Binding Protein HuR Regulates Splicing Programs in Osteocytes2025
  5. 5Combined Deletion of miR-27a and miR-27b Enhances Protection Against Diet-Induced Obesity2025