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September 5, 2025Frontiers in Cardiovascular MedicineOpen Access

The nonlinear association between the triglyceride glucose-waist-to-height ratio index and cardiovascular disease among middle-aged and older adults in China with cardiovascular-kidney-metabolic syndrome stages 0–3

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Authors

CHCheng HuangJJJing JiaYHYuanyuan He

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Overview

Observational study reveals a significant association between TyG-WHtR and cardiovascular disease risk, suggesting critical implications for health management.

Key Points

  • A nonlinear association exists between TyG-WHtR and cardiovascular disease risk among middle-aged and older adults.
  • Adjusted hazard ratio for CVD risk increased from 1.09 to 1.17 beyond an inflection point of 3.57.
  • Cox proportional hazards models and restricted cubic spline regression evaluated associations over a mean follow-up period of 7.77 years.
  • Findings underscore the importance of monitoring TyG-WHtR in managing cardiovascular disease risk among adults with CKM syndrome.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/68c23922b210217d6477aba3https://doi.org/10.3389/fcvm.2025.1604270
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The association between triglyceride glucose-waist height ratio index and cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study2025
  2. 2Comparison of triglyceride-glucose index and triglyceride-glucose related indexes in predicting cardiovascular disease incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study2025
  3. 3Associations of cumulative exposure and longitudinal change patterns of the triglyceride glucose–Chinese visceral adiposity index with incident cardiovascular disease in middle-aged and older adults: evidence from CHARLS2026
  4. 4Comparative analysis of 16 baseline obesity and lipid-related indices for cardiovascular disease risk prediction in adults with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study2025 · 12 citations
  5. 5Association of Triglyceride-Glucose-Frailty Index with Cardiovascular Disease and All-Cause Mortality Incidence in Individuals with Cardiovascular-Kidney-Metabolic Syndrome Stages 0–3: A Nationwide Prospective Cohort Study2026