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August 19, 2025Diabetology & Metabolic SyndromeOpen Access

Comparative analysis of 16 baseline obesity and lipid-related indices for cardiovascular disease risk prediction in adults with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study

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Authors

YPYilin PanBDBeibei DuLFLong Feng

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Overview

Prospective cohort study compares obesity and lipid-related indices for cardiovascular disease risk, highlighting TyG-WC's predictive value.

Key Points

  • The study revealed that the TyG-WC index has the strongest association with cardiovascular disease risk among various indices.
  • During the 6-year follow-up, 1,134 new cardiovascular disease events were reported among 5,782 participants aged 45 or older.
  • This prospective cohort study utilized Cox proportional hazards models to assess the risk prediction abilities of 16 obesity-related indices.
  • The findings suggest that TyG-WC can effectively stratify cardiovascular disease risk in adults within different stages of CKM syndrome.

Cite This Study

Pan et al. (2025) studied this question.

synapsesocial.com/papers/68af35ddcf1dd9ea359e9e09https://doi.org/10.1186/s13098-025-01919-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of triglyceride-glucose index and triglyceride-glucose related indexes in predicting cardiovascular disease incidence among populations with cardiovascular-kidney-metabolic syndrome stages 0-3: a nationwide prospective cohort study2025
  2. 2Insulin resistance surrogate indices and incident cardiovascular disease across cardiovascular–kidney–metabolic stages 0–3: a prospective cohort study2026 · 1 citations
  3. 3The nonlinear association between the triglyceride glucose-waist-to-height ratio index and cardiovascular disease among middle-aged and older adults in China with cardiovascular-kidney-metabolic syndrome stages 0–32025
  4. 4Association of 14 triglyceride-glucose (TyG)-related indices with new-onset cardiovascular disease in middle-aged and older adults: evidence from the CHARLS and ELSA aging cohorts2026 · 1 citations
  5. 5The small dense LDL cholesterol-glucose index combined with visceral adiposity (sdLG-cVAI) as a novel predictor of incident cardiovascular disease: a prospective cohort study2026