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September 10, 2025Journal of Lipid ResearchOpen Access

Lipid and Lipoprotein Metabolism in Microglia: Alzheimer’s Disease Mechanisms and Interventions

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Authors

KSKayla G. SprengerELEmma E LeitzkeJMJohn Melchior

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Overview

This review explores lipid metabolism and microglial dysfunction in Alzheimer's disease, indicating potential therapeutic strategies.

Key Points

  • Microglial lipid metabolism alterations significantly impact Alzheimer's disease pathology and progression.
  • Research identifies genes related to lipid processing in microglia as crucial Alzheimer's disease risk factors.
  • Interventions promoting healthy lipid handling in microglia may mitigate Alzheimer's disease symptoms and pathology.
  • Therapies targeting lipid droplet accumulation and triglyceride levels in microglia hold promise for Alzheimer's treatment.

Cite This Study

Sprenger et al. (2025) studied this question.

synapsesocial.com/papers/68c24236b210217d647a25bbhttps://doi.org/10.1016/j.jlr.2025.100872
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health2025
  2. 2Lipids in the Pathogenesis of Alzheimers Disease2025
  3. 3Microglial Neuroinflammation in Alzheimer’s Disease: Mechanisms and Therapies2025
  4. 4APOE4 reprograms microglial lipid metabolism in Alzheimer's disease: Mechanisms and therapeutic implications2025
  5. 5Microglial lipid droplets as therapeutic targets in age-related neurodegenerative diseases2025