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September 5, 2025Advanced ScienceOpen Access

Insights into the Mechanisms of Immune‐Checkpoint Inhibitors Gained from Spatiotemporal Dynamics of the Tumor Microenvironment

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Authors

YZYuanyuan ZhangZLZhihua Liu

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Overview

This review explores tumor microenvironment features influencing immune checkpoint inhibitors, suggesting key immune cell roles in therapy effectiveness.

Key Points

  • Enhanced understanding of immune cell dynamics in the tumor microenvironment reveals insights into immune checkpoint inhibitors' effectiveness.
  • Significant emphasis is placed on how stromal components and microbiota affect immune cell behavior and alter immune checkpoint inhibitor responses.
  • This review highlights the phenotypic plasticity and functional adaptability of immune cells as critical elements influencing responses to immunotherapy.
  • Recent advances in single-cell technologies have facilitated profound insights into tumor microenvironment characteristics across various cancer types.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68c238d2b210217d64779d42https://doi.org/10.1002/advs.202508692
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploration of the Mechanism of Action of Immune Checkpoint Inhibitors and Their Advancements in Cancer Immunotherapy2025
  2. 2Soil and Seed: Tumor Microenvironment Nurtures Immunotherapy Resistance and Renewal2025
  3. 3Tumor Microenvironmental Dynamics in Shaping Resistance to Therapeutic Interventions in Melanoma: A Narrative Review2025
  4. 4Checkpoint inhibitors in cancer Immunotherapy: Mechanisms, Resistance, and Combination Strategies2026
  5. 5Analyzing Strategies to Enhance the Efficacy of Immune Checkpoint Inhibitors for Cancer Immunotherapy2024