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July 23, 2025PharmaceuticalsOpen Access

Tumor Microenvironmental Dynamics in Shaping Resistance to Therapeutic Interventions in Melanoma: A Narrative Review

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Authors

LTLaci TurnerHTHanna TerhaarVJVictoria Jiminez

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Overview

Narrative review highlights immune cells and resistance mechanisms in melanoma, suggesting implications for immunotherapy.

Key Points

  • Melanoma's resistance to immune checkpoint inhibitors involves complex interactions in the tumor microenvironment.
  • Key resistance factors include reduced CD8+ T cell infiltration and the presence of immunosuppressive cytokines.
  • Cancer-associated fibroblasts and myeloid-derived suppressor cells alter the tumor microenvironment to promote growth.
  • Predictive biomarkers may enhance personalized therapy and improve the management of melanoma treatment resistance.

Cite This Study

Turner et al. (2025) studied this question.

synapsesocial.com/papers/689a061be6551bb0af8cdac0https://doi.org/10.3390/ph18081082
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