December 8, 2025BloodOpen Access

Construction of a prognostic model for new diffuse large B-cell lymphoma and research on risk factors for secondary central nervous system infiltration

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This analysis builds a prognostic model for overall survival in DLBCL, highlighting p53 mutations and systemic factors as key contributors.

Prognostic model achieved AUC values over 0.7 for predicting OS in DLBCL patients.
Key risk factor POD6 increased likelihood of poor outcomes with high-risk indicators yielding HR = 5.13.
Assessment involved next-generation sequencing and concordance index to analyze adverse factors like p53 and bcl2.
Enhanced model shows clinical relevance in predicting central nervous system involvement and overall survival outcomes.

Hou et al. (2025) studied this question.

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December 8, 2025BloodOpen Access

View Full Paper

Ask AI

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Authors

This analysis builds a prognostic model for overall survival in DLBCL, highlighting p53 mutations and systemic factors as key contributors.

Prognostic model achieved AUC values over 0.7 for predicting OS in DLBCL patients.
Key risk factor POD6 increased likelihood of poor outcomes with high-risk indicators yielding HR = 5.13.
Assessment involved next-generation sequencing and concordance index to analyze adverse factors like p53 and bcl2.
Enhanced model shows clinical relevance in predicting central nervous system involvement and overall survival outcomes.

Hou et al. (2025) studied this question.

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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