December 8, 2025BloodOpen Access

IFN-γ drives long-term bone marrow niche dysfunction following chemotherapy

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Doxorubicin exposure leads to persistent bone marrow niche dysfunction, impacting hematopoietic stem cell maintenance.
Key findings reveal diminished donor hematopoietic stem cell pools 16 weeks post-transplant in doxorubicin-treated hosts.
Experimental approach included single cell transcriptomics and cytokine assays to investigate niche alterations.
Targeting interferon gamma may offer therapeutic avenues to mitigate long-term complications from chemotherapy.

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Implication

Experimental analysis shows that doxorubicin impairs hematopoietic stem cell maintenance in the bone marrow niche, indicating a crucial role for interferon gamma in this process.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d752 https://doi.org/10.1182/blood-2025-863

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Implication

Experimental analysis shows that doxorubicin impairs hematopoietic stem cell maintenance in the bone marrow niche, indicating a crucial role for interferon gamma in this process.

IFN-γ drives long-term bone marrow niche dysfunction following chemotherapy

Key Points

Discussion

Implication

Cite This Study

IFN-γ drives long-term bone marrow niche dysfunction following chemotherapy

Key Points

Discussion

Implication

Cite This Study

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