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December 8, 2025BloodOpen Access

Human bone scaffolds support clonal persistence and functional retention of MDS-derived CD34+ cells in a 3D in vitro bone marrow model

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Authors

LBLisa BurgerIPI.S. ParkVNVerena Nowak

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Overview

In vitro analysis shows enhanced retention of CD34+ cells in bone scaffolds, indicating their potential in personalized medicine for MDS.

Key Points

  • Human bone scaffolds maintained superior CD34+ cell viability compared to hydroxyapatite.
  • Colony-forming unit assays revealed 6-fold higher colony counts in scaffolds after 21 days of culture.
  • Analysis included single-cell RNA sequencing to assess clonal stability and hematopoietic retention.
  • Potential for improving personalized medicine applications in myelodysplastic neoplasms through optimized bone scaffolds.

Cite This Study

Burger et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d8c3https://doi.org/10.1182/blood-2025-675
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