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September 17, 2025Acta Microbiologica et Immunologica Hungarica

Activity of ceftazidime-avibactam combinations against carbapenem-resistant Klebsiella pneumoniae assessed by checkerboard method

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Authors

SGSerpil GençAUAyten Nur UzunHTHilal Tanriverdi

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Overview

Analysis of synergistic effects of ceftazidime-avibactam mixtures with colistin and meropenem on CRKP.

Key Points

  • Ceftazidime-avibactam-meropenem showed the highest synergy against carbapenem-resistant Klebsiella pneumoniae.
  • 17.1% of isolates demonstrated synergy with ceftazidime-avibactam-meropenem in the study of 35 CRKP isolates.
  • Ceftazidime-avibactam combinations were tested using the checkerboard method for determining effectiveness.
  • The findings suggest new treatment strategies against resistant K. pneumoniae, highlighting ongoing therapeutic challenges.

Cite This Study

Genç et al. (2025) studied this question.

synapsesocial.com/papers/68d43294713b0b5dfea72284https://doi.org/10.1556/030.2025.02686
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A Tentative Clinical Study: Colistin Combined with Ceftazidime/Avibactam in the Treatment of Carbapenem-Resistant Gram-Negative Bacilli Infection2025 · 2 citations
  2. 2Analysis of a simple disk diffusion method to evaluate Ceftazidime-avibactam/Aztreonam combination synergism against NDM clinical isolates.2025
  3. 3Global susceptibility profiles and potential resistance mechanisms of ceftazidime–avibactam-resistant, non-carbapenemase-producing carbapenem-resistant Enterobacterales: 2020–23 data from the Antimicrobial Testing Leadership and Surveillance2025 · 1 citations
  4. 4Evaluation of Ceftazidime-Avibactam Susceptibility in Carbapenem-Resistant Gram-Negative Bacteria2025
  5. 5Comparison of Antimicrobial Activity between Ceftriaxone-Sulbactam-Disodium EDTA and Ceftazidime-Avibactam against Carbapenemase Producing Enterobacterales Isolates from a Tertiary Care Hospital: An In-vitro Study2025