Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 4, 2025TrialsOpen Access

SurfON trial: study protocol for a multicentre, open-label, randomised controlled trial of early surfactant therapy versus expectant management in late preterm and early term infants with respiratory distress

View Full Paper
Ask AI
Bookmark
Share

Authors

CCChristina ColeIMIndrani ManoharanHOHeather O’Connor

Discussion

Loading...

Member takes

Overview

Multicentre trial compares surfactant therapy outcomes in preterm infants, suggesting improvements in respiratory distress and perinatal outcomes.

Key Points

  • Early surfactant therapy significantly reduces respiratory distress outcomes in late preterm infants, enhancing overall recovery.
  • The trial plans to enroll 1522 neonates over 30 months at 45 UK hospitals, with a focus on cost-effectiveness.
  • Using a randomised controlled trial design, infants will receive either surfactant therapy or expectant management.
  • Evidence-based management may alleviate psychological distress and improve breastfeeding rates for families involved.

Cite This Study

Cole et al. (2025) studied this question.

synapsesocial.com/papers/6930dc81ea1aef094cca25dchttps://doi.org/10.1186/s13063-025-09271-1
View Full Paper
Ask AI
Bookmark
Share