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September 25, 2025Current Drug Metabolism

Targeting Metabolic Dysregulation in Alzheimer’s Disease: A Potential Therapeutic Strategy

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Authors

NBNivedita BarnwalSDSonal DubeyPTPrashant Tiwari

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Overview

This review demonstrates the potential therapeutic strategies targeting metabolic dysfunction in Alzheimer's disease, highlighting insulin resistance and oxidative stress.

Key Points

  • Therapeutic approaches targeting metabolic pathways show promise in mitigating Alzheimer's disease pathology.
  • Key metabolic disruptions include insulin resistance and reduced cerebral glucose utilization linked to neurodegeneration.
  • Potential interventions like ketogenic diets and mitochondrial antioxidants may improve treatment outcomes for Alzheimer's patients.
  • Future research needs to focus on identifying reliable biomarkers and designing targeted metabolic interventions to aid patient outcomes.

Cite This Study

Barnwal et al. (2025) studied this question.

synapsesocial.com/papers/68d5d12cddad3c16d46364c6https://doi.org/10.2174/0113892002408089250912080734
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Therapeutic Challenges and Perspectives in Alzheimer’s Disease: A Critical Review of the AGE-RAGE Axis, Oxidative Stress, and Metabolic Dysfunctions2025
  2. 2Bioenergetics and lipid metabolism in Alzheimer's disease: From cell biology to systemic health2025
  3. 3Targeting Inflammation in Alzheimer’s Disease: Insights Into Pathophysiology and Therapeutic Avenues-A Comprehensive Review2025
  4. 4Pathological mechanisms and treatment progression of Alzheimer’s disease2025 · 72 citations
  5. 5Adipokines at the Metabolic–Brain Interface: Therapeutic Modulation by Antidiabetic Agents and Natural Compounds in Alzheimer’s Disease2025 · 12 citations