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August 31, 2024Journal of Student ResearchOpen Access

CAR-T Cell Therapy for Solid Tumors: A Review of Challenges and Emerging Solutions

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Authors

DHDaojun HongALAna Leda F. Longhini

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Overview

Review highlights emerging solutions for car-t cell therapy in solid tumors, indicating potential to improve immunotherapy.

Key Points

  • CAR-T cell therapy may improve outcomes in solid tumors, yet faces significant challenges in efficacy.
  • Key hurdles include the immunosuppressive tumor microenvironment and poor T-cell infiltration, which limits treatment efficacy.
  • Innovative approaches are discussed, such as engineering CAR-T cells to express checkpoint blockade inhibitors or modify their cytokine profiles.
  • Enhancing T-cell homing through regional delivery methods and chemokine receptor modifications may significantly boost therapeutic effectiveness.

Cite This Study

Hong et al. (2024) studied this question.

synapsesocial.com/papers/68af7f4b7567bf4f94ff6b3ahttps://doi.org/10.47611/jsrhs.v13i3.7230
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advancing CAR-T Therapy for Solid Tumors: From Barriers to Clinical Progress2025 · 16 citations
  2. 2Advancements and challenges in CAR-T cell therapy for solid tumors: A comprehensive review of antigen targets, strategies, and future directions2025
  3. 3Can We Use CAR-T Cells to Overcome Immunosuppression in Solid Tumours?2025
  4. 4Advancing CAR T-Cell Therapy in Solid Tumors: Current Landscape and Future Directions2025 · 30 citations
  5. 5From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies2025