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September 10, 2025CancersOpen Access

Advancing CAR T-Cell Therapy in Solid Tumors: Current Landscape and Future Directions

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Authors

SRSaeed RafiiDMDeborah MukherjiAKAshok S. Komaranchath

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Overview

Review uncovers advancements in CAR T-cell therapy for solid tumors, indicating novel approaches to address challenges.

Key Points

  • CAR T-cell therapy shows promise in solid tumors, gradually overcoming unique challenges in treatment.
  • Recent FDA approvals highlight effective CAR therapies in melanoma and synovial sarcoma, suggesting broad applicability.
  • Innovative strategies, including dual-antigen targeting and checkpoint blockade, are critical for improving tumor response.
  • Artificial intelligence-guided target discovery may enhance future CAR T-cell development for various malignancies.

Cite This Study

Rafii et al. (2025) studied this question.

synapsesocial.com/papers/68c23b08b210217d64783546https://doi.org/10.3390/cancers17172898
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