Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 23, 2025Cancer Cell InternationalOpen Access

Advancements and challenges in CAR-T cell therapy for solid tumors: A comprehensive review of antigen targets, strategies, and future directions

View Full Paper
Ask AI
Bookmark
Share

Authors

JZJiajun ZhuJZJianming ZhouYTYing Tang

Discussion

Loading...

Member takes

Overview

Comprehensive review highlights antigen targets and emerging strategies for CAR-T cell therapy in solid tumors, indicating ongoing challenges.

Key Points

  • Initial clinical trials of car-t cell therapy for solid tumors reveal limited success due to specific challenges.
  • Promising strategies such as combination therapies and gene editing technologies show potential for enhancing treatment effectiveness.
  • Current challenges include targeting antigen scarcity, overcoming the immunosuppressive microenvironment, and addressing adverse reactions.
  • Ongoing research aims to integrate car-t cell therapy into standard cancer treatment options for improved patient outcomes.

Cite This Study

Zhu et al. (2025) studied this question.

synapsesocial.com/papers/68af782c7567bf4f94ff0afahttps://doi.org/10.1186/s12935-025-03938-0
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Advancing CAR T-Cell Therapy in Solid Tumors: Current Landscape and Future Directions2025 · 30 citations
  2. 2Challenges and breakthroughs: current landscape and future prospects of CAR-T cell therapy clinical trials for solid tumors2025
  3. 3Advancing CAR-T Therapy for Solid Tumors: From Barriers to Clinical Progress2025 · 16 citations
  4. 4CAR-T Cell Therapy for Solid Tumors: A Review of Challenges and Emerging Solutions2024
  5. 5From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies2025 · 7 citations