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August 25, 2025Advanced ScienceOpen Access

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

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Authors

YCYang ChenRRRan RenLYLirong Yan

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Overview

This review explores challenges and advancements in car‐t therapy for solid tumors, suggesting improved treatments may emerge through innovative technologies and combination strategies.

Key Points

  • CAR‐T therapy shows potential for reshaping treatment in patients with solid tumors, as new strategies develop.
  • Recent trials in gastric cancer and glioma reveal promising clinical potential in enhancing car‐t efficacy.
  • Assessment of advancements like crispr editing and cytokine armoring aims to improve tumor specificity and T-cell persistence.
  • Ongoing research into combination strategies could further enhance the effectiveness of car‐t therapy, highlighting its impact on precision oncology.

Cite This Study

Chen et al. (2025) studied this question.

synapsesocial.com/papers/68af7c8d7567bf4f94ff3de6https://doi.org/10.1002/advs.202505822
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