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August 26, 2025Frontiers in PhysiologyOpen Access

Effect of exercise on brain-derived neurotrophic factors in middle-aged and older adults with type 2 diabetes mellitus: a systematic review and meta-analysis

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Authors

ZLZhihua LiZCZhanglin Lin CuiTWTong Wang

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Overview

Systematic review shows exercise boosts brain-derived neurotrophic factor in adults with type 2 diabetes, suggesting chronic activity is key.

Key Points

  • Exercise significantly increases brain-derived neurotrophic factor levels in adults with type 2 diabetes.
  • Involved 206 participants across 13 studies, demonstrating a standardized mean difference of 0.73.
  • Meta-analysis employed a random-effects model with non-instant blood sampling methods identifying significant increases.
  • Chronic exercise and over 150 minutes weekly show a greater impact on BDNF levels, indicating a need for ongoing activity.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/68af7c8d7567bf4f94ff3d7ahttps://doi.org/10.3389/fphys.2025.1599980
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 12760-LB: Optimal Dose and Exercise Modality to Improve Glycemic Control in Older Adults with Type 2 Diabetes: A Systematic Review and Network Meta-analysis2026
  2. 2Exercise as Modulator of Brain-Derived Neurotrophic Factor in Adolescents: A Systematic Review of Randomized Controlled Trials2025 · 6 citations
  3. 3Exercise modalities and dosages on glycated haemoglobin and exerkines in type 2 diabetes: a systematic review with pairwise, network, and dose-response meta-analyses2026 · 1 citations
  4. 4Exercise as Modulator of Brain-Derived Neurotrophic Factor (BDNF) in Children: A Systematic Review of Randomized Controlled Trials2025 · 15 citations
  5. 5Acute cardiovascular exercise and circulating neurotrophic factors in humans: A systematic review and meta-analysis of mechanisms and methodological moderators2026 · 2 citations