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July 22, 2025LifeOpen Access

Exercise as Modulator of Brain-Derived Neurotrophic Factor (BDNF) in Children: A Systematic Review of Randomized Controlled Trials

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Authors

MRMarkel Rico-GonzálezDGDaniel González-DevesaCGCarlos D. Gómez‐Carmona

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Overview

Systematic review reveals exercise improves BDNF in children, suggesting neuromotor activities enhance cognitive development.

Key Points

  • Structured physical exercise increases brain-derived neurotrophic factor (BDNF) levels in healthy children.
  • Two out of five studies showed significant BDNF increases post-exercise, particularly with neuromotor activities.
  • Most interventions involved training frequencies of at least three times per week over a duration of 12 weeks.
  • Finding highlights the need for engaging physical activities in schools to support cognitive growth during development.

Cite This Study

Rico-González et al. (2025) studied this question.

synapsesocial.com/papers/689a0614e6551bb0af8cd689https://doi.org/10.3390/life15071147
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Also Consider

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  1. 1Exercise as Modulator of Brain-Derived Neurotrophic Factor in Adolescents: A Systematic Review of Randomized Controlled Trials2025
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  3. 3Acute cardiovascular exercise and circulating neurotrophic factors in humans: A systematic review and meta-analysis of mechanisms and methodological moderators2026 · 2 citations
  4. 4Effect of exercise on brain-derived neurotrophic factors in middle-aged and older adults with type 2 diabetes mellitus: a systematic review and meta-analysis2025 · 5 citations
  5. 5Impact of probiotic supplementation on serum levels of brain-derived neurotrophic factor: GRADE-based dose-response meta-analysis2025