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August 2, 2025SportsOpen Access

Exercise as Modulator of Brain-Derived Neurotrophic Factor in Adolescents: A Systematic Review of Randomized Controlled Trials

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Authors

MRMarkel Rico-GonzálezUniversity of the Basque CountryDGDaniel González-DevesaCatholic University of ÁvilaCGCarlos D. Gómez‐CarmonaUniversity of Alicante

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Implication

Systematic review analyzes exercise impacts on brain-derived neurotrophic factor in adolescents, suggesting vigorous activities boost levels.

Key Points

  • MAIN FINDING: Exercise positively influences brain-derived neurotrophic factor levels in adolescents, but results are inconsistent.
  • KEY EVIDENCE: Of the 8 trials reviewed, 4 showed significant BDNF increases with high-intensity exercise lasting 6 weeks or more.
  • APPROACH: The systematic review followed PRISMA guidelines and included various exercise modalities and quality assessments.
  • SIGNIFICANCE: Understanding exercise's impact on BDNF can inform interventions for enhancing adolescent neurodevelopment.

Cite This Study

Rico-González et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d00b1https://doi.org/10.3390/sports13080253
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