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September 10, 2025General Physiology and BiophysicsOpen Access

HuR enhances the stability of FGF19 mRNA to suppress Kupffer cell activation and mitigate inflammation and fibrosis in non-alcoholic fatty liver disease

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Authors

XMXiaoqing MoSZSong ZhouXZXiaoge Zhou

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Overview

Animal and in vitro analysis shows that HuR reduces KC activation and liver inflammation in NAFLD, suggesting new therapeutic strategies.

Key Points

  • Overexpression of huR significantly reduces liver inflammation and fibrosis in NAFLD, improving overall liver health.
  • In vitro results indicate that suppressing kupffer cell activation is key to mitigating inflammation and fibrosis.
  • Animal models treated with a high-fat diet exhibit decreased huR expression linked to NAFLD progression.
  • This research reveals a potential therapeutic target in the interaction between huR and fgf19 for treating NAFLD.

Cite This Study

Mo et al. (2025) studied this question.

synapsesocial.com/papers/68c23b4ab210217d647842abhttps://doi.org/10.4149/gpb_2025023
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